HotDog Express File1.03Bluefade!HotDog Junior Version 1.5 Document$ 1 (Largest)Lipitorgraphics\lipitor3d.jpg395576ÿÿÿÿhttp://graphics\lipitor.gif227315ÿÿÿÿhttp:// 2 (Larger) Basic Info- Common name: Lipitor - Chemical Name: [R-(R*, R*)]-2-(4-fluorophenyl)-b, d -dihydroxy-5- (1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate - Purpose: Lower bad cholstorol and raise good cholestorolÿÿÿÿ 6 (Thickest) 1 (Largest)Biochemical Effects4 (Small)Lipitor inhibiting processgraphics\lipitoraction.gif353450ÿÿÿÿhttp://wLipitor inhibits the catalyzing of HMG-CoA reductase. HMG-CoA reductase is a major initial step enzyme for cholestorol.ÿÿÿÿ 6 (Thickest) 1 (Largest)Other possible benefits°- may reduce risk of heart disease - may affect Alzheimers disease Safer than Zoco and some other prescription cholestorol lowering drugs because also reduces inflammationÿÿÿÿ 6 (Thickest) 1 (Largest) Side Effects4 (Small)Rare Side Effects Include:ò- Muscle problems and liver problems - Muscle pain, tenderness, or weakness - Fever or Flulike symptoms - Yellowing of the skin or eyes - Abdominal Pain - Unexplained Fatigue - Dark Colored Urine - Pale Colored Stool 4 (Small)Serious Side Effects Include:µ- Allergic Reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives - Decreased Urine or Rust Colored Urine - Blurred Vision graphics\adversaffects.jpg485473ÿÿÿÿhttp://Í Table shows percentages of occurences with different doses versus placebos. Overall occurence of side effects were equal to or less than occurence with placebo ÿÿÿÿ 6 (Thickest) 1 (Largest)Things To Avoidx-Large Amounts of Alcohol -Grapefruit or Grapefruit Juice (reacts with Cytochrome P450 which helps break down drugs) graphics\grapefruit.jpg87116ÿÿÿÿhttp://ÿÿÿÿ 6 (Thickest)3 (Large)Typical Lipitor Tabsgraphics\lipitortabs.jpg374300ÿÿÿÿhttp://graphics\lipitorcompany.jpg62111ÿÿÿÿhttp://www.pfizer.com3 (Large)#Sites that contributed to this page:ÿÿÿÿ3http://http://www.uky.edu/Pharmacy/ps/porter/CPR.htmCytochrome P450ÿÿÿÿÿÿÿÿ©http://chem.sis.nlm.nih.gov/chemidplus/ProxyServlet?objectHandle=DBMaint&actionHandle=default&nextPage=jsp/chemidheavy/ResultScreen.jsp&ROW_NUM=0&TXTSUPERLISTID=134523038ChemIDPlus LipitorÿÿÿÿÿÿÿÿRhttp://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00055.txtDrug Bank: Atorvastatinÿÿÿÿÿÿÿÿ1http://www.rxlist.com/cgi/generic/atorvastatin.htmRX Listÿÿÿÿ3 (Large)Sources:0-Gorman, Christine. "Judging Statins." Time 163.12 (2004): 73. - Petanceska, Suzana. "Modulation of Alzheimer's Amyloidosis by Statins: Mechanisms of Action." Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents 3.1 (2003) 1-8 - "Why Some Statins Work Better." Time 164.11 (2004) ÿÿÿÿEnd nd od of of of Hf Ho HotHotDotDotDogDog og Eg Ex ExpExprxprepresressess ss Fs Fi FilFileile le >e >= >=)>=)=)a)aÚ